Which of the following is TRUE according to the passage?

Despite their widespread popularity, collagen supplements must undergo stringent FDA evaluations for therapeutic effectiveness before reaching consumers.

Relying exclusively on synthetic collagen supplements is considered the most effective strategy to counteract the age-related deterioration of the skin.

The human body completely ceases its natural collagen production immediately after an individual reaches the age of forty.

While collagen supplements show potential in easing joint discomfort, their definitive anti-aging effects still require further scientific validation.